https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41111 Wed 13 Mar 2024 14:21:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19442 Sat 24 Mar 2018 08:02:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35336 Mon 20 Nov 2023 15:56:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42787 ABCG2, SLC2A9, SLC17A1, SLC22A11, and SLC22A12 showed consistent causal effects of urate on HDL-C from all methods with 0.038 to 0.057 SD decrease in HDL-C per 1 mg/dl increase of urate, and no evidence of horizontal pleiotropy was detected. Conclusion: Our study suggests a significant and robust causal effect of genetically predicted urate on HDL-C. This finding may explain a small proportion (7%) of the association between increased urate and cardiovascular disease but points to urate being a novel cardiac risk factor.]]> Fri 02 Sep 2022 14:02:17 AEST ]]>